Somatic & Germline Variant Ingestion
Modern medical oncologists face hundreds of pages of unstandardized PDF reports from molecular genetics laboratories. OncoCare ingests structured Variant Call Format (VCF) files and parsed molecular pathology reports directly into the longitudinal patient chart.
- Standardized nomenclature: HGVS cDNA and protein change notation
- Classification according to AMP/ASCO/CAP Tier I (strong clinical significance) to Tier IV (benign)
- Automated extraction of Tumor Mutational Burden (TMB) and Microsatellite Instability (MSI-H / dMMR)
Targeted Therapy & Biomarker Matching
Instantly correlate detected mutations with approved targeted therapies, resistance mechanisms, and guideline-concordant combinations:
- Lung Malignancies (NSCLC): EGFR (Exon 19 del, L858R, T790M, Exon 20 ins), ALK, ROS1, BRAF V600E, MET exon 14 skipping, RET, and KRAS G12C
- Breast Malignancies: ER/PR, HER2 IHC/FISH, PIK3CA, BRCA1/BRCA2, ESR1 resistance mutations
- Colorectal & GI Malignancies: KRAS/NRAS codon 12/13/61, BRAF V600E, HER2 amplification, MSI-H immune checkpoint eligibility
Molecular Tumor Board (MTB) Presentation Suite
When standard lines of chemotherapy fail, Molecular Tumor Boards convene to evaluate off-label targeted options and compassionate drug access. OncoCare assembles variant allele frequencies (VAF), prior therapy response timelines, and ongoing Indian CTRI clinical trials into a single collaborative slide-free view.